HHNerve Chex™ has been formulated with a combination of vitamins, minerals, herbs and glandulars to support a healthy mood [1].  Some of the specific components are discussed below:

Acerola Cherry is a naturally dense form of Food vitamins C that contains bioflavonoids.  “Vitamin C may have anti-hypertensive activity…{its} antioxidant effects are well established” [2].

Nerve Chex™ contains multiple New Zealand Bovine Glandulars. New Zealand is a nation that has never had a case of BSE (bovine spongiform encephalopathy) [3-4]. Brain tissue contains “specific brain cell activators” [5]. They have been advised for slowness of thought, loss of memory, uncontrolled mental activity, nightmares, mental retardation, and epilepsy [6-7].

• Bovine Hypothalamus provides hypothalamus tissue, it is responsible for neural and endocrine functions.  “In any situation where the endocrine system is particularly resistant to balancing, the hypothalamus should be considered” [7].
• Bovine Liver has been included in this formulation due to its detoxifying ability. The liver is the chemical factory of the body and makes hundreds of substances which help throughout the body [1].
• Bovine Orchic supplies orchic tissue.  “The orchic affects somatic development, fat distribution, and psychic development” [7]. The late Royal Lee recommended it for those with hyperirritability, nervous tension, lowered tolerance to stress, low mood, “loss of psychic tone,” insecurity, “mental aberrations,” and “[l]ack of feeling of well-being” [8]. He also wrote that supplementation with it improved oxygenation and he believed vitamin B-6 worked well with these glands [9].
• Bovine Spleen tissue, it is the body’s largest lymphatic organ.  Part of the blood-cleansing function of the spleen is the removal of old or weak cells [1]. Supplementation was helpful for those with hyperirritability [10].

  Calcium supports healthy blood pressure as well as bone and muscle health [2]. Calcium supplementation was helpful for those with hyperirritability [11] and {it} can affect mood [12-13].

  Kelp is a Food high in minerals, especially iodine [14].  “Kelp can rebalance thyroid metabolism, resulting in successful weight management and the reversal of many conditions which are caused by a thyroid imbalance, including stomach and respiratory disorders” [15].

  “Magnesium… plays a vital modulatory role in brain biochemistry, influencing several neurotransmission pathways associated with the development of depression” [16]. Manganese… “appears to affect manganese homeostasis in the brain, probably followed by alteration of neural activity” [17] and can affect mood [18].

  Niacinamide has been found to improve mood [19]. Combined with vitamin B-6, Royal Lee advised it to people with “psychic manifestation,” melancholia, sensitivity to sunlight, as well as nervousness [20].

  Para-Aminobenzoic Acid is known as PABA, it was once considered to be a B vitamin [21]. “A deficiency of PABA may lead to depression, fatigue, gastrointestinal disorders, graying of the hair, irritability, nervousness and patchy areas of the white skin” [22].

  Vitamin B-6 is an essential nutrient [2]. “{It} is involved in the regulation of mental function and mood… Epidemiological studies indicate that poor vitamin B6 status is common among older people.  Hyperhomocysteinaemia has been suggested as a cause or mechanism in the development of Alzheimer’s disease and other forms of dementia…” [23].

  Vitamin B-12 has many functions including memory and mood [2]. Royal Lee wrote that vitamin B-12 was helpful for those with “slowness of thought” and apathy [24]. The vitamin B-12 in Nerve Chex is methylated.

  Clinically, people who have taken Nerve Chex™ have reported mood improvements.

   

References

[1] Guyton AG, Hall JE. Textbook of Medical Physiology, 9th ed. W.B. Saunders Co., Phil., 1996

[2] Hendler SS, Rorvik D, editors. PDR for Nutritional Supplements. Physicians Desk Reference, Inc., 2008

[3] Ross C, et al. Modern Nutrition in Health & Disease, 11th ed. Lippincott Williams & Wilkins, Balt., 2014

[4] Martinelli D, et al. Cobalamin C defect: natural history, pathophysiology, and treatment. J Inherit Metab Dis. 2011 Feb;34(1):127-35

[5] Lee R. Therapeutic Food Manual, Lee Foundation for Nutritional Research, Milwaukee, circa 1950;14

[6] Lee R. Brain Cytotrophin. Lee Foundation for Nutritional Research, Milwaukee, circa 1950

[7] Profiles in Nutritional Progress. Rubicon Productions, Bakersfield, 1993

[8] Cenacchi T, et al. Cognitive decline in the elderly: a double-blind placebo-controlled multicenter study on the efficacy of phosphatidylserine administration. Aging Clin Exp Res 5:123-133, 1993

[9] Null G. The Complete Encyclopedia of Natural Healing. Kensington Books, 1998

[10] Dean W, Morgenthaler J, Fowkes SW. Phosphatidylserine. In Smart Drugs II: The Next Generation. Smart Publications, Petaluma (CA), 1993:75-80

[11] JOINT STATEMENT FROM THE NEW ZEALAND FOOD SAFETY AUTHORITY AND MINISTRY OF AGRICULTURE AND FORESTRY. BSE in the US has no food safety impact in New Zealand or threat to our animal health status. 24 December 2003

[12] New Zealand’s Scrapie Freedom. New Zealand Food Safety Authority. Nzfsa.gov2/16/06

[13] Lee R. Brain Orchex. Product Bulletin 36. Lee Foundation for Nutritional Research, Milwaukee, circa 1950

[14] Versendaal DA. Contact Reflex Analysis and Applied Trophology. DA Versendaal, 1990

[15] Lee R. Spleen Cytotrophin. Product Bulletin 36. Lee Foundation for Nutritional Research, Milwaukee, circa 1950

[16] Lee R. Calcium Lactate. Product Bulletin 1. Lee Foundation for Nutritional Research, Milwaukee, circa 1950

[17] Feno S, et al. Crosstalk between Calcium and ROS in Pathophysiological Conditions. Oxid Med Cell Longev. 2019 Apr 24;2019:9324018

[18] Luptok M, Hroudová J. Important role of mitochondria and the effect of mood stabilizers on mitochondrial function. Physiol Res. 2019 Nov 22;68(Suppl 1):S3-S15

[19] Seaweed, kelp, raw. USDA Nutrient Database for Standard Reference, Release 11-1, August 1997

[20] Robbins J, Rall JE, Gorden P. The thyroid and iodine metabolism. In Duncan’s Diseases of Metabolism, 7th ed. WB Saunders, Phil.:1009-1104, 1974

[21] Serefko A. Magnes Res. 2016 Mar 1;29(3):112-119

[22] Ismael AAA, et al. Chronic magnesium deficiency and human disease; time for reappraisal? QJM. 2018 Nov 1;111(11):759-763

[23] Vinson J. Bioavailability of magnesium. University of Scranton, Scranton (PA), 1991

[24] Frequently Asked Questions. www.albionlabs.com July 19, 2002