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“Choline is crucial for sustaining life. It modulates the basic signaling processes within cells, is a structured element in membranes, and is vital during critical periods in brain development”. It was discovered in 1862, yet it was not recognized as a required nutrient for humans until 1998.

“Choline has several important functions:  it is a source of methyl groups needed to make S-adenosylmethionine, it is a part of the neurotransmitter acetylcholine, and it is a part of the predominant phospholipids in membranes (phosphatidylcholine and sphingomyelin).  Betaine, formed from choline, is an important osmolyte in the kidney glomerulus and helps with the reabsorption of water from the kidney tubule.  Although they represent a smaller proportion of the total choline pool, important metabolites of choline include platelet-activating factor, choline plasmalogens, lysophosphatidylcholine, phosphocholine, and glycerophosphocholine” [1].  

Regarding Choline, WebMD reports, “Athletes use it for bodybuilding and delaying fatigue in endurance sports” [2].  Low levels of Cholinehave been found in endurance athletes and supplementation may decrease fatigue during exercise [3].  

The official Recommended Daily Intake of Choline is as low as 125 mg per day for infants up to 6 months of age to as high as 550 mg per day for lactating women (the RDI for non-lactating women is 450 mg per day) [1].  The RDI for adult males is 550 mg per day [1].   
Many people simply take choline to feel better. 

* This is a nutritional product and not a medication intended to prevent, treat, or cure any illness. None of these statements has been approved by the US FDA or similar agencies. Not all citations meet peer-reviewed status so the statements are not conclusive. Professionals can, and do, disagree, regarding efficacy of ingredients in nutritional formulas.

Disclaimer: Some of these studies (or citations) may not confom to peer review standards. Therefore, the results are not conclusive. Profressionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA